Setting up wireless printing on the HP DeskJet 2621 printer is straightforward. Begin by ensuring the printer and your wireless router are powered on. On the printer's control panel, navigate to the "Wireless" or "Network" settings and select "Wireless Setup Wizard." Choose your network from the available list and enter the Wi-Fi password. Once connected, install the HP printer software on your computer. During installation, select the wireless connection option and follow prompts.